Shared Fate of Meningeal Mast Cells and Sensory Neurons in Migraine
نویسندگان
چکیده
منابع مشابه
The role of mast cells in migraine pathophysiology.
Mast cells are critical players in allergic reactions, but they have also been shown to be important in immunity and recently also in inflammatory diseases, especially asthma. Migraines are episodic, typically unilateral, throbbing headaches that occur more frequently in patients with allergy and asthma implying involvement of meningeal and/or brain mast cells. These mast cells are located peri...
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Intracranial headaches such as migraine are thought to result from activation of sensory trigeminal pain neurons that supply intracranial blood vessels and the meninges, also known as meningeal nociceptors. Although the mechanism underlying the triggering of such activation is not completely understood, our previous work indicates that the local activation of the inflammatory dural mast cells c...
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This study investigated the presence of mast cells in inflammatory aural polyps using light microscopy. The number of mast cells was increased in all examined cases and varied from 2.33 to 41.54 per mm2• The cells were located most commonly around small blood vessels. Occurrence of mast cells was not different in various types of polyps, but their density was severely increased in active in...
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Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible relationship between increased number of mast cells and clinical and histological p...
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Objective(s): To reach an evidence-based knowledge in the context of the temporal-spatial pattern of neuronal death and find appropriate time of intervention in order to preserve spared neurons and promote regeneration after traumatic spinal cord injury (TSCI). Materials and Methods: The study design was based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-guided...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2019
ISSN: 1662-5102
DOI: 10.3389/fncel.2019.00136